I am using Doppler as my podcatching client.  I was all bummed that I thought my "OPML" lists of all my podcasts that I subscribe to was lost in my recent HD crash. 

It turns out I was very wrong.  Doppler stores those files in the place where you want your Podcasts physically stored.  I had a back up of that folder (in My Documents), and yes a back up of the Doppler config files also. 

So, I think the only thing I really ended up losing was: 8 hours of email, my Firefox bookmarks, and stuff I stupidly put on my desktop.